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Publication : Effect of bovine growth hormone administration on the pattern of thymic involution in mice.

First Author  Bar-Dayan Y Year  1994
Journal  Thymus Volume  23
Issue  2 Pages  95-101
PubMed ID  7725388 Mgi Jnum  J:22852
Mgi Id  MGI:70740 Citation  Bar-Dayan Y, et al. (1994) Effect of bovine growth hormone administration on the pattern of thymic involution in mice. Thymus 23(2):95-101
abstractText  Age-related decline of the thymus in mice was reversed by repeated injections of bovine growth hormone. After hormone administration that was begun at 5, 8, or 11.5 months of age, the cortical volume fraction (Vc), cortical/medullary ratio (C/M) and thymocyte numbers found were in the range obtained with younger mice. Growth hormone injection reduced the slope of the curves for Vc and C/M as a function of age, indicating a slowing down of the involution process.
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