| First Author | Dong WG | Year | 2015 |
| Journal | Front Aging Neurosci | Volume | 7 |
| Pages | 148 | PubMed ID | 26283960 |
| Mgi Jnum | J:288950 | Mgi Id | MGI:6433555 |
| Doi | 10.3389/fnagi.2015.00148 | Citation | Dong WG, et al. (2015) Electroacupuncture Reduces Abeta Production and BACE1 Expression in SAMP8 Mice. Front Aging Neurosci 7:148 |
| abstractText | Electroacupuncture (EA) has been reported to have beneficial effects on Alzheimer's disease (AD). BACE1 (beta-site amyloid precursor protein-cleaving enzyme 1) is involved in the abnormal production of amyloid-beta plaque (Abeta), a hallmark of AD pathophysiology. Thus, the present study investigated the effects of EA on memory impairment, Abeta production, and BACE1 expression in senescence-accelerated mouse prone 8 (SAMP8) mice. We found that EA improved spatial learning and memory impairment of SAMP8 mice. Furthermore, EA attenuated Abeta production and repressed the expression of BACE1 in the hippocampus of SAMP8 mice. Taken together, our results suggest that EA could have a potential therapeutic application in AD and that BACE1 may be an important target of EA in the treatment of AD. |
