| Primary Identifier | IPR036739 | Type | Homologous_superfamily |
| Short Name | SLC41_membr_dom_sf |
| description | The SLC41 superfamily of divalent cation transporters includes MgtE (SLC41A1), SLC41A2 and SLC41A3. The prokaryote orthologue, MgtE, is a magnesium transporter []. MgtE consists of a C-terminal transmembrane domain and a N-terminal cytosolic domain, and adopts a homodimeric architecture in bateria []. Mouse SLC41A2 has been shown to transport Mg2+ and a range of other divalent cations: Ba2+, Ni2+, Co2+, Fe2+, or Mn2+, but not Ca2+, Zn2+, or Cu2+ [].This entry represents the integral membrane region of SLC41 transporter proteins. Bacterial family members have one copy of this region while archaeal and eukaryotic sequences have two. This suggests that the bacterial proteins may act as dimers. |
