Primary Identifier | MGI:1859515 | Organism | mouse, laboratory |
Chromosome | 6 | NCBI Gene Number | 54137 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable peptidase activator activity. Involved in acrosome assembly and fertilization. Located in acrosomal vesicle. Is expressed in testis. Orthologous to human ACRBP (acrosin binding protein). PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced male fertility associated with aberrant formation of the acrosomal granule, a fragmented acrosome structure, an abnormally condensed nuclear structure, and decreased sperm motility. [provided by MGI curators] |