| Primary Identifier | IPR037566 | Type | Family |
| Short Name | Complement_C8_beta |
| description | This entry represents the beta chain of complement component C8. C8 is a complex of three chains, alpha, beta and gamma []. C8 is a component of the membrane attack complex (MAC) which forms pores in the membranes of cells of invading organisms. MAC forms when C5 is cleaved into C5a and C5b, and C5b binds sequentially C6, C7, C8 and multiple copies of the pore-forming subunit C9 [, ]. C8 beta is synthesized as a precursor and activation occurs by cleavage by kallikrein-related peptidase 4 []. The tertiary structure of C8 beta has been solved and shows the following domains (N- to C-terminal): first TSP type-1, LDL-receptor class A, MACPF, EGF-like, second TSP type-1 []. This domain architecture is shared with the alpha chain of C8. |
