| First Author | Malhotra N | Year | 2013 |
| Journal | Immunity | Volume | 38 |
| Issue | 4 | Pages | 681-93 |
| PubMed ID | 23562159 | Mgi Jnum | J:196163 |
| Mgi Id | MGI:5486619 | Doi | 10.1016/j.immuni.2013.01.010 |
| Citation | Malhotra N, et al. (2013) A network of high-mobility group box transcription factors programs innate interleukin-17 production. Immunity 38(4):681-93 |
| abstractText | How innate lymphoid cells (ILCs) in the thymus and gut become specialized effectors is unclear. The prototypic innate-like gammadelta T cells (Tgammadelta17) are a major source of interleukin-17 (IL-17). We demonstrate that Tgammadelta17 cells are programmed by a gene regulatory network consisting of a quartet of high-mobility group (HMG) box transcription factors, SOX4, SOX13, TCF1, and LEF1, and not by conventional TCR signaling. SOX4 and SOX13 directly regulated the two requisite Tgammadelta17 cell-specific genes, Rorc and Blk, whereas TCF1 and LEF1 countered the SOX proteins and induced genes of alternate effector subsets. The T cell lineage specification factor TCF1 was also indispensable for the generation of IL-22 producing gut NKp46(+) ILCs and restrained cytokine production by lymphoid tissue inducer-like effectors. These results indicate that similar gene network architecture programs innate sources of IL-17, independent of anatomical origins. |
