| Primary Identifier | MGI:5308398 | Allele Type | Transgenic |
| Attribute String | Humanized sequence, Inserted expressed sequence | Gene | Tg(Thy1-TARDBP*G298S)S97Pcw |
| Strain of Origin | (C57BL/6 x SJL)F1 | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | This transgene contains the mouse Thy1 (thymus cell antigen 1, theta, promoter (Thy1.2)) promoter driving expression of the full-length human TAR DNA binding protein (TARDBP) cDNA sequence. A missense mutation associated with amyotrophic lateral sclerosis (ALS) was introduced at position 298 results in a glycine-to-serine substitution (G298S). Line S97 was established. |
