| First Author | Pala D | Year | 2008 |
| Journal | J Biol Chem | Volume | 283 |
| Issue | 14 | Pages | 9239-47 |
| PubMed ID | 18276598 | Mgi Jnum | J:135567 |
| Mgi Id | MGI:3794128 | Doi | 10.1074/jbc.M705175200 |
| Citation | Pala D, et al. (2008) Focal adhesion kinase/Src suppresses early chondrogenesis: central role of CCN2. J Biol Chem 283(14):9239-47 |
| abstractText | Adhesive signaling plays a key role in cellular differentiation, including in chondrogenesis. Herein, we probe the contribution to early chondrogenesis of two key modulators of adhesion, namely focal adhesion kinase (FAK)/Src and CCN2 (connective tissue growth factor, CTGF). We use the micromass model of chondrogenesis to show that FAK/Src signaling, which mediates cell/matrix attachment, suppresses early chondrogenesis, including the induction of Ccn2, Agc, and Sox6. The FAK/Src inhibitor PP2 elevates Ccn2, Agc, and Sox6 expression in wild-type mesenchymal cells in micromass culture, but not in cells lacking CCN2. Our results suggest a reduction in FAK/Src signaling is a critical feature permitting chondrogenic differentiation and that CCN2 operates downstream of this loss to promote chondrogenesis. |
