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Protein Coding Gene : Tab1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
Primary Identifier  MGI:1913763 Organism  mouse, laboratory
Chromosome  15 NCBI Gene Number  66513
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.4.0)

Enables kinase activator activity. Acts upstream of or within several processes, including circulatory system development; positive regulation of MAPK cascade; and transforming growth factor beta receptor signaling pathway. Predicted to be located in nuclear speck. Predicted to be part of protein-containing complex. Predicted to be active in cytosol and endoplasmic reticulum membrane. Is expressed in brain and genitourinary system. Orthologous to human TAB1 (TGF-beta activated kinase 1 (MAP3K7) binding protein 1).
PHENOTYPE: Homozygous mutant fetuses exhibit edema, hemorrhaging, cardiovascular and pulmonary dysmorphogenesis, and die in the late stages of gestation. [provided by MGI curators]
  • synonyms:
  • RIKEN cDNA 2310012M03 gene,
  • Tak1-binding protein 1,
  • Map3k7ip1,
  • Mutant line 449,
  • Tab1,
  • mitogen-activated protein kinase kinase kinase 7 interacting protein 1,
  • TGF-beta activated kinase 1/MAP3K7 binding protein 1,
  • 2310012M03Rik,
  • b2b449Clo,
  • MGI:5314038
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Features --> Cross References

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3 Involved In Mutations

Trail: ProteinCodingGene

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0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

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Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

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Function

Mouse features --> Functions (GO terms)

Homology

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Interactions

45 Pathways

Trail: ProteinCodingGene

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Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

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