| First Author | Scarff KL | Year | 2001 |
| Journal | Immunology | Volume | 104 |
| Issue | 4 | Pages | 392-401 |
| PubMed ID | 11899424 | Mgi Jnum | J:73103 |
| Mgi Id | MGI:2154575 | Doi | 10.1046/j.1365-2567.2001.01327.x |
| Citation | Scarff KL, et al. (2001) Requirements for autoimmune responses to mouse gastric autoantigens. Immunology 104(4):392-401 |
| abstractText | Autoimmune gastritis, in which the H+/K(+)-ATPase of parietal cells is the major antigen, is one of the most common autoimmune diseases. Here we examined if specific properties of the H+/K(+)-ATPase or parietal cells are involved in rendering them autoimmune targets. The model antigens beta-galactosidase and ovalbumin (OVA) were expressed in parietal cells of transgenic mice. On experimental induction of autoimmune gastritis by neonatal thymectomy, autoantibodies to beta-galactosidase developed in mice expressing beta-galactosidase in parietal cells, a response that was independent of either the response to the gastric H+/K(+)-ATPase or gastric inflammation. In contrast, mice that expressed OVA in parietal cells did not exhibit an antibody response to OVA after thymectomy. However, increasing the frequency of anti-OVA T lymphocytes in OVA-expressing mice resulted in autoantibodies to OVA and gastritis. These studies indicate that parietal cells can present a variety of antigens to the immune system. Factors such as the identity and expression level of the autoantigen and the frequency of autoreactive T cells play a role in determining the prevalence and outcome of the particular immune response. In addition, as not all mice of a particular genotype displayed autoimmunity, random events are involved in determining the target of autoimmune recognition. |
