| First Author | Marth JD | Year | 1985 |
| Journal | Cell | Volume | 43 |
| Issue | 2 Pt 1 | Pages | 393-404 |
| PubMed ID | 2416464 | Mgi Jnum | J:8130 |
| Mgi Id | MGI:56599 | Doi | 10.1016/0092-8674(85)90169-2 |
| Citation | Marth JD, et al. (1985) A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA. Cell 43(2 Pt 1):393-404 |
| abstractText | Protein-tyrosine kinases are implicated in the control of normal and neoplastic cell growth. We have used molecular cloning strategies to characterize a lymphocyte-specific protein-tyrosine kinase gene distinct from but closely related to src and yes. This gene, encoded by a genetic locus defined here as lskT, is rearranged and overexpressed in the murine T cell lymphoma LSTRA. Thus alterations in the structure or expression of this protein-tyrosine kinase gene may in some cases mediate neoplastic transformation. In addition, transcription of the normal lskT gene is restricted to cells of lymphoid origin. We infer that the lskT-encoded protein-tyrosine kinase may aid in transducing proliferative or differentiative signals unique to lymphocytes. |
