| First Author | Prlic M | Year | 2001 |
| Journal | J Immunol | Volume | 167 |
| Issue | 10 | Pages | 5664-8 |
| PubMed ID | 11698438 | Mgi Jnum | J:118723 |
| Mgi Id | MGI:3700300 | Doi | 10.4049/jimmunol.167.10.5664 |
| Citation | Prlic M, et al. (2001) Homeostatic expansion occurs independently of costimulatory signals. J Immunol 167(10):5664-8 |
| abstractText | Naive T cells undergo homeostatic proliferation in lymphopenic mice, a process that involves TCR recognition of specific self peptide/MHC complexes. Since costimulation signals regulate the T cell response to foreign Ags, we asked whether they also regulate homeostatic expansion. We report in this study that homeostatic expansion of CD4 and CD8 T cells occurs independently of costimulation signals mediated through CD28/B7, CD40L/CD40, or 4-1BB/4-1BBL interactions. Using DO11.10 TCR transgenic T cells, we confirmed that CD28 expression was dispensable for homeostatic expansion, and showed that the presence of endogenous CD4(+)CD25(+) regulatory cells did not detectably influence homeostatic expansion. The implications of these findings with respect to regulation of T cell homeostasis and autoimmunity are discussed. |
