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Publication : Nucleotide sequence of cDNA clones of the murine myb proto-oncogene.

First Author  Gonda TJ Year  1985
Journal  EMBO J Volume  4
Issue  8 Pages  2003-8
PubMed ID  2998780 Mgi Jnum  J:17641
Mgi Id  MGI:65674 Doi  10.1002/j.1460-2075.1985.tb03884.x
Citation  Gonda TJ, et al. (1985) Nucleotide sequence of cDNA clones of the murine myb proto-oncogene. EMBO J 4(8):2003-8
abstractText  We have isolated cDNA clones of murine c-myb mRNA which contain approximately 2.8 kb of the 3.9-kb mRNA sequence. Nucleotide sequencing has shown that these clones extend both 5' and 3' to sequences homologous to the v-myb oncogenes of avian myeloblastosis virus and avian leukemia virus E26. The sequence contains an open reading frame of 1944 nucleotides, and could encode a protein which is both highly homologous, and of similar size (71 kd), to the chicken c-myb protein. Examination of the deduced amino acid sequence of the murine c-myb protein revealed the presence of a 3-fold tandem repeat of 52 residues near the N terminus of the protein, and has enabled prediction of some of the likely structural features of the protein. These include a high alpha-helix content, a basic region toward the N terminus of the protein and an overall globular configuration. The arrangement of genomic c-myb sequences, detected using the cDNA clones as probes, was compared with the reported structure of rearranged c-myb in certain tumour cells. This comparison suggested that the rearranged c-myb gene may encode a protein which, like the v-myb protein, lacks the N-terminal region of c-myb.
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