Primary Identifier | MGI:1916449 | Organism | mouse, laboratory |
Chromosome | 10 | NCBI Gene Number | 213402 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.4.0) Involved in sperm axoneme assembly. Acts upstream of or within several processes, including cilium organization; flagellated sperm motility; and spermatogenesis. Is expressed in brain; reproductive system; respiratory system; spinal cord; and thyroid gland. Used to study male infertility. Human ortholog(s) of this gene implicated in spermatogenic failure 38. Orthologous to human ARMC2 (armadillo repeat containing 2). PHENOTYPE: Mice homozygous for a knock-out allele exhibit male infertility, oligozoospermia, immotile sperm, and teratozoospermia associated with severe sperm flagellum malformations. [provided by MGI curators] |