| First Author | Cai Y | Year | 2014 |
| Journal | Nat Commun | Volume | 5 |
| Pages | 3986 | PubMed ID | 24909159 |
| Mgi Jnum | J:225218 | Mgi Id | MGI:5691869 |
| Doi | 10.1038/ncomms4986 | Citation | Cai Y, et al. (2014) Differential developmental requirement and peripheral regulation for dermal Vgamma4 and Vgamma6T17 cells in health and inflammation. Nat Commun 5:3986 |
| abstractText | Dermal IL-17-producing gammadeltaT cells have a critical role in skin inflammation. However, their development and peripheral regulation have not been fully elucidated. Here we demonstrate that dermal gammadeltaT cells develop from the embryonic thymus and undergo homeostatic proliferation after birth with diversified TCR repertoire. Vgamma6T cells are bona fide resident, but precursors of dermal Vgamma4T cells may require extrathymic environment for imprinting skin-homing properties. Thymic Vgamma6T cells are more competitive than Vgamma4 for dermal gammadeltaT cell reconstitution and TCRdelta(-/-) mice reconstituted with Vgamma6 develop psoriasis-like inflammation after IMQ-application. Although both IL-23 and IL-1beta promote Vgamma4 and Vgamma6 proliferation, Vgamma4 are the main source of IL-17 production that requires IL-1 signalling. Mice with deficiency of IL-1RI signalling have significantly decreased skin inflammation. These studies reveal a differential developmental requirement and peripheral regulation for dermal Vgamma6 and Vgamma4 gammadeltaT cells, implying a new mechanism that may be involved in skin inflammation. |
