| First Author | Zhao L | Year | 2021 |
| Journal | Mucosal Immunol | Volume | 14 |
| Issue | 2 | Pages | 420-430 |
| PubMed ID | 32773769 | Mgi Jnum | J:349762 |
| Mgi Id | MGI:6728597 | Doi | 10.1038/s41385-020-0333-3 |
| Citation | Zhao L, et al. (2021) Coordinated co-migration of CCR10(+) antibody-producing B cells with helper T cells for colonic homeostatic regulation. Mucosal Immunol 14(2):420-430 |
| abstractText | In the intestine, IgA antibody-secreting B cells (IgA-ASCs) and helper T cells coordinate to maintain local homeostasis while their dysregulation could lead to development of intestinal inflammatory diseases. However, mechanisms underlying the coordinated localization and function of the B and T cells into the intestine, particularly the colon, are poorly understood. We herein report the first evidence that the gut-homing chemokine receptor CCR10(+) IgA-ASCs form conjugates with helper T cells, preferentially regulatory T cells, at their differentiation sites of gut-associated lymphoid organs for their coordinated co-localization into the colon to promote local homeostasis. In CCR10-knockout mice, defective migration of IgA-ASCs also resulted in defective T-cell migration and homeostasis, and development of inflammatory symptoms in the colon. Antigen-specific interaction of CCR10(+) IgA-ASCs and T cells is crucial for their homeostatic establishment in the colon. On the other hand, in IgA-knockout mice, preferential expansion of CCR10(+) IgG1-ASCs with regulatory functions compensated for CCR10(+) IgA-ASCs to help maintain colonic homeostasis. The preferential expansion of specific subclasses of CCR10(+) IgG-ASCs with regulatory functions was also found in asymptomatic IgA-deficient patients. These findings suggest coordinated cell migration as a novel mechanism underlying localization and function of B and T cells in colonic homeostatic regulation. |
