| First Author | Kishimoto H | Year | 2001 |
| Journal | Nat Immunol | Volume | 2 |
| Issue | 11 | Pages | 1025-31 |
| PubMed ID | 11668341 | Mgi Jnum | J:72650 |
| Mgi Id | MGI:2153363 | Doi | 10.1038/ni726 |
| Citation | Kishimoto H, et al. (2001) A defect in central tolerance in NOD mice. Nat Immunol 2(11):1025-31 |
| abstractText | The predisposition of nonobese diabetic (NOD) mice to develop autoimmune disease is usually attributed to defects in peripheral tolerance mechanisms. Here, evidence is presented that NOD mice display a defect in central tolerance (negative selection) of thymocytes. Impaired central tolerance in NOD mice was most prominent in a population of semi-mature thymocytes found in the medulla. The defect was apparent in vivo as well as in vitro, was independent of IAbetag7 expression and affected both Fas-dependent and Fas-independent pathways of apoptosis; for Fas-dependent apoptosis, the defective tolerance of NOD thymocytes correlated with the strong T cell receptor-mediated up-regulation of caspase 8-homologous FLICE (Fas-associated death-domain-like interleukin 1beta-converting enzyme)-inhibitory protein. In light of these findings, disease onset in NOD mice may reflect defects in central as well as peripheral tolerance. |
