| Primary Identifier | IPR040131 | Type | Domain |
| Short Name | MnmG_N |
| description | MnmG (also known as GidA) is a tRNA modification enzyme found in bacteria and mitochondria. MnmG forms a complex with MnmE which is involved in the formation of methyluridine derivatives at the wobble uridine base in some tRNAs [, , ].This domain is also found in the MnmG paralogue TrmFo, a folate/FAD-dependent methyltransferase that catalyzes the methylation of the C5-uridine 54 in the T-loop of tRNAs of most Gram-positive bacteria and some Gram-negative bacteria [, ]. TrmFO lacks a C-terminal helical domain present in MnmG [].This entry represents the N-terminal domain of MnmG and related domains. This domain does not include the C-terminal region of MnmG, which contains a sterile alpha motif domain and is responsible for tRNA-protein and protein-protein interactions including association with MnmE [, ]. |
