Primary Identifier | MGI:1920174 | Organism | mouse, laboratory |
Chromosome | 9 | NCBI Gene Number | 68743 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable actin binding activity. Acts upstream of or within hematopoietic progenitor cell differentiation. Predicted to be located in several cellular components, including bleb; midbody; and nucleoplasm. Predicted to be active in actomyosin contractile ring. Is expressed in several structures, including blood; brain; heart; and otocyst. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis 8. Orthologous to human ANLN (anillin, actin binding protein). PHENOTYPE: Mice homozygous for a knock-out allele show delayed embryonic development with poorly organized epithelia and complete embryonic lethality by E9.5. [provided by MGI curators] |