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Publication : Pip92: a short-lived, growth factor-inducible protein in BALB/c 3T3 and PC12 cells.

First Author  Charles CH Year  1990
Journal  Mol Cell Biol Volume  10
Issue  12 Pages  6769-74
PubMed ID  2247083 Mgi Jnum  J:23755
Mgi Id  MGI:71446 Doi  10.1128/mcb.10.12.6769
Citation  Charles CH, et al. (1990) Pip92: a short-lived, growth factor-inducible protein in BALB/c 3T3 and PC12 cells. Mol Cell Biol 10(12):6769-74
abstractText  pip92 is a cellular immediate-early gene inducible by serum growth factors in fibroblasts. It is also induced in the rat pheochromocytoma cell line PC12 by agents that cause proliferation, neuronal differentiation, and membrane depolarization. We show that the pip92-encoded polypeptide is a proline-rich protein of 221 amino acids, has an extremely short half-life, and is localized in the cytoplasm. We hypothesize that Pip92 plays a role in mediating the cellular responses to a variety of extracellular signals.
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