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Publication : CPI motif interaction is necessary for capping protein function in cells.

First Author  Edwards M Year  2015
Journal  Nat Commun Volume  6
Pages  8415 PubMed ID  26412145
Mgi Jnum  J:227213 Mgi Id  MGI:5699926
Doi  10.1038/ncomms9415 Citation  Edwards M, et al. (2015) CPI motif interaction is necessary for capping protein function in cells. Nat Commun 6:8415
abstractText  Capping protein (CP) has critical roles in actin assembly in vivo and in vitro. CP binds with high affinity to the barbed end of actin filaments, blocking the addition and loss of actin subunits. Heretofore, models for actin assembly in cells generally assumed that CP is constitutively active, diffusing freely to find and cap barbed ends. However, CP can be regulated by binding of the 'capping protein interaction' (CPI) motif, found in a diverse and otherwise unrelated set of proteins that decreases, but does not abolish, the actin-capping activity of CP and promotes uncapping in biochemical experiments. Here, we report that CP localization and the ability of CP to function in cells requires interaction with a CPI-motif-containing protein. Our discovery shows that cells target and/or modulate the capping activity of CP via CPI motif interactions in order for CP to localize and function in cells.
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