| First Author | Corcoran LM | Year | 1984 |
| Journal | Cell | Volume | 37 |
| Issue | 1 | Pages | 113-22 |
| PubMed ID | 6327047 | Mgi Jnum | J:7436 |
| Mgi Id | MGI:55906 | Doi | 10.1016/0092-8674(84)90306-4 |
| Citation | Corcoran LM, et al. (1984) Murine T lymphomas in which the cellular myc oncogene has been activated by retroviral insertion. Cell 37(1):113-22 |
| abstractText | The myc oncogene is implicated here in T lymphocyte neoplasia. Cloning revealed a retroviral insert 0.7-1.3 kb 5' to c-myc in two T lymphomas induced by Soule murine leukemia virus and in a spontaneous T lymphoma ( Tikaut ) of an AKR mouse, a strain in which leukemogenesis involves recombinant retroviruses (MCF viruses). The tumor c-myc mRNAs appear normal but their level is approximately 5-fold higher than in most T lymphomas lacking c-myc rearrangement. Since each insert would be transcribed away from c-myc, its activation cannot involve the promoter of the long terminal repeat (LTR) but could reflect an enhancer, like that demonstrated within the Soule LTR. The Tikaut provirus has an MCF-like recombinant env gene and LTR sequence. MCF-like inserts were found near c-myc in seven of 31 other AKR T lymphomas; two lie 3' to c-myc and the five upstream are oriented away from c-myc. We conclude that a quarter of retrovirus-induced T lymphomas involve activation of c-myc, probably via the LTR enhancer. |
