| First Author | Daniels MA | Year | 2001 |
| Journal | Immunity | Volume | 15 |
| Issue | 6 | Pages | 1051-61 |
| PubMed ID | 11754824 | Mgi Jnum | J:110509 |
| Mgi Id | MGI:3640431 | Doi | 10.1016/s1074-7613(01)00252-7 |
| Citation | Daniels MA, et al. (2001) CD8 binding to MHC class I molecules is influenced by T cell maturation and glycosylation. Immunity 15(6):1051-61 |
| abstractText | CD8 serves both as an adhesion molecule for class I MHC molecules and as a coreceptor with the TCR for T cell activation. Here we study the developmental regulation of CD8-mediated binding to noncognate peptide/MHC ligands (i.e., those not bound by the TCR). We show that CD8's ability to bind soluble class I MHC tetramers and to mediate T cell adhesion under shear flow conditions diminishes as double-positive thymocytes mature into CD8(+) T cells. Furthermore, we provide evidence that this decreased CD8 binding results from increased T cell sialylation upon T cell maturation. These data suggest that CD8's ability to interact with class I MHC is not fixed and is developmentally regulated through the T cell's glycosylation state. |
