| Primary Identifier | IPR038363 | Type | Homologous_superfamily |
| Short Name | LepA_C_sf |
| description | The elongation factor 4 (LepA or GUF1 in Saccaromyces) is a GTP-binding membrane protein related to EF-G and EF-Tu. LepA is a noncanonical GTPase that has an unknown function. It is highly conserved and present in bacteria, mitochondria, and chloroplasts []. LepA contains domains that are homologous to EF-G domain I, II, III, V. However, it also contains a C-terminal domain (CTD) that is not homologous to any region in EF-G. This entry represents the unique C-terminal region of LepA []. The CTD of LepA may play a primary role in back translocation by providing additional binding interactions with a back-translocated tRNA []. |
