| First Author | Rigter PMF | Year | 2022 |
| Journal | Front Neurosci | Volume | 16 |
| Pages | 1086994 | PubMed ID | 36685241 |
| Mgi Jnum | J:333365 | Mgi Id | MGI:7429796 |
| Doi | 10.3389/fnins.2022.1086994 | Citation | Rigter PMF, et al. (2022) Loss of CAMK2G affects intrinsic and motor behavior but has minimal impact on cognitive behavior. Front Neurosci 16:1086994 |
| abstractText | INTRODUCTION: The gamma subunit of calcium/calmodulin-dependent protein kinase 2 (CAMK2G) is expressed throughout the brain and is associated with neurodevelopmental disorders. Research on the role of CAMK2G is limited and attributes different functions to specific cell types. METHODS: To further expand on the role of CAMK2G in brain functioning, we performed extensive phenotypic characterization of a Camk2g knockout mouse. RESULTS: We found different CAMK2G isoforms that show a distinct spatial expression pattern in the brain. Additionally, based on our behavioral characterization, we conclude that CAMK2G plays a minor role in hippocampus-dependent learning and synaptic plasticity. Rather, we show that CAMK2G is required for motor function and that the loss of CAMK2G results in impaired nest-building and marble burying behavior, which are innate behaviors that are associated with impaired neurodevelopment. DISCUSSION: Taken together, our results provide evidence for a unique function of this specific CAMK2 isozyme in the brain and further support the role of CAMK2G in neurodevelopment. |
