| First Author | Khader SA | Year | 2006 |
| Journal | J Exp Med | Volume | 203 |
| Issue | 7 | Pages | 1805-15 |
| PubMed ID | 16818672 | Mgi Jnum | J:124401 |
| Mgi Id | MGI:3721473 | Doi | 10.1084/jem.20052545 |
| Citation | Khader SA, et al. (2006) Interleukin 12p40 is required for dendritic cell migration and T cell priming after Mycobacterium tuberculosis infection. J Exp Med 203(7):1805-15 |
| abstractText | Migration of dendritic cells (DCs) to the draining lymph node (DLN) is required for the activation of naive T cells. We show here that migration of DCs from the lung to the DLN after Mycobacterium tuberculosis (Mtb) exposure is defective in mice lacking interleukin (IL)-12p40. This defect compromises the ability of IL-12p40-deficient DCs to activate naive T cells in vivo; however, DCs that express IL-12p40 alone can activate naive T cells. Treatment of IL-12p40-deficient DCs with IL-12p40 homodimer (IL-12(p40)(2)) restores Mtb-induced DC migration and the ability of IL-12p40-deficient DCs to activate naive T cells. These data define a novel and fundamental role for IL-12p40 in the pathogen-induced activation of pulmonary DCs. |
