| First Author | Wu L | Year | 1994 |
| Journal | Immunol Lett | Volume | 40 |
| Issue | 2 | Pages | 89-92 |
| PubMed ID | 7522220 | Mgi Jnum | J:18578 |
| Mgi Id | MGI:66841 | Doi | 10.1016/0165-2478(94)90177-5 |
| Citation | Wu L, et al. (1994) Functional analysis of Mel-14+ and Mel-14- early precursor cells in the adult mouse thymus. Immunol Lett 40(2):89-92 |
| abstractText | The earliest T-cell precursor population in the adult mouse thymus (low CD4 precursors) may be divided into 85% of cells expressing surface Mel-14 (LECAM-1, the lymphocyte homing receptor) and 15% of cells which are Mel-14. To date, this is the only surface marker for which we have found this population to be heterogeneous. The precursor activity of the Mel-14+ and Mel-14- subpopulation was assessed by both intrathymic and intravenous transfer of sorted cells into Ly5 congenic irradiated recipient mice. On both a cell-for-cell and a total activity basis, almost all precursor activity was associated with the Mel-14+ cells. No segregation was seen between T-cell, B-cell and dendritic cell precursor activity of the low CD4 population, all activities being concentrated in the Mel-14+ fraction. This strengthens the hypothesis that one precursor cell has the potential to form all three lineages. |
