| First Author | Harvill ET | Year | 2008 |
| Journal | Infect Immun | Volume | 76 |
| Issue | 5 | Pages | 2177-82 |
| PubMed ID | 18316379 | Mgi Jnum | J:134474 |
| Mgi Id | MGI:3788956 | Doi | 10.1128/IAI.00647-07 |
| Citation | Harvill ET, et al. (2008) Anamnestic protective immunity to Bacillus anthracis is antibody mediated but independent of complement and Fc receptors. Infect Immun 76(5):2177-82 |
| abstractText | The threat of bioterrorist use of Bacillus anthracis has focused urgent attention on the efficacy and mechanisms of protective immunity induced by available vaccines. However, the mechanisms of infection-induced immunity have been less well studied and defined. We used a combination of complement depletion along with immunodeficient mice and adoptive transfer approaches to determine the mechanisms of infection-induced protective immunity to B. anthracis. B- or T-cell-deficient mice lacked the complete anamnestic protection observed in immunocompetent mice. In addition, T-cell-deficient mice generated poor antibody titers but were protected by the adoptive transfer of serum from B. anthracis-challenged mice. Adoptively transferred sera were protective in mice lacking complement, Fc receptors, or both, suggesting that they operate independent of these effectors. Together, these results indicate that antibody-mediated neutralization provides significant protection in B. anthracis infection-induced immunity. |
