| First Author | Huang Q | Year | 2014 |
| Journal | Biochem Biophys Res Commun | Volume | 453 |
| Issue | 1 | Pages | 160-5 |
| PubMed ID | 25264196 | Mgi Jnum | J:220214 |
| Mgi Id | MGI:5632469 | Doi | 10.1016/j.bbrc.2014.09.076 |
| Citation | Huang Q, et al. (2014) MiR-30a inhibits osteolysis by targeting RunX2 in giant cell tumor of bone. Biochem Biophys Res Commun 453(1):160-5 |
| abstractText | RunX2 has been identified to crucially regulate the osteolysis in giant cell tumor of bone. MiR-30a is an intronic miRNA identified as tumor suppressor, but little is known about its role in giant tumor cell of bone. In our research, we reported miR-30a was down-regulated in GCT whereas RunX2 was highly expressed. Further research proved that miR-30a can regulate the expression of RunX2 by binding to its 3'-UTR, which influence the osteoclast differentiation and osteolysis formation. Thus, these results suggest that miR-30a could directly target RunX2 and participate in osteolysis in GCT. |
