| First Author | Wei R | Year | 2015 |
| Journal | Cell Signal | Volume | 27 |
| Issue | 3 | Pages | 578-86 |
| PubMed ID | 25555806 | Mgi Jnum | J:306367 |
| Mgi Id | MGI:6709076 | Doi | 10.1016/j.cellsig.2014.12.013 |
| Citation | Wei R, et al. (2015) NEDL2 is an essential regulator of enteric neural development and GDNF/Ret signaling. Cell Signal 27(3):578-86 |
| abstractText | Although glial cell line-derived neurotrophic factor (GDNF)/Ret signaling is essential for enteric nervous system (ENS) development, the positive regulators regulating GDNF/Ret signaling and controlling ENS development are poorly understood. Here, we show that Nedd4-related E3 ubiquitin ligase-2 (NEDL2) plays an essential and positive physiological role in regulating ENS development and GDNF/Ret signaling. All of the NEDL2-deficient mice die within 2weeks after birth, showing low body weight. These mice showed a progressive bowel motility defect resulting from intestinal aganglionosis. We show that NEDL2 positively regulates enteric neural precursor proliferation through the GDNF/Akt signaling pathway. Together, these findings unveil the physiological function of NEDL2 in vivo. |
