| First Author | Wang H | Year | 2009 |
| Journal | Science | Volume | 326 |
| Issue | 5959 | Pages | 1554-7 |
| PubMed ID | 20007903 | Mgi Jnum | J:155805 |
| Mgi Id | MGI:4415747 | Doi | 10.1126/science.1178496 |
| Citation | Wang H, et al. (2009) Norbin is an endogenous regulator of metabotropic glutamate receptor 5 signaling. Science 326(5959):1554-7 |
| abstractText | Metabotropic glutamate receptor 5 (mGluR5) is highly expressed in the mammalian central nervous system (CNS). It is involved in multiple physiological functions and is a target for treatment of various CNS disorders, including schizophrenia. We report that Norbin, a neuron-specific protein, physically interacts with mGluR5 in vivo, increases the cell surface localization of the receptor, and positively regulates mGluR5 signaling. Genetic deletion of Norbin attenuates mGluR5-dependent stable changes in synaptic function measured as long-term depression or long-term potentiation of synaptic transmission in the hippocampus. As with mGluR5 knockout mice or mice treated with mGluR5-selective antagonists, Norbin knockout mice showed a behavioral phenotype associated with a rodent model of schizophrenia, as indexed by alterations both in sensorimotor gating and psychotomimetic-induced locomotor activity. |
