Primary Identifier | MGI:88611 | Organism | mouse, laboratory |
Chromosome | 4 | NCBI Gene Number | 13117 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0) Predicted to enable monooxygenase activity. Predicted to be involved in fatty acid metabolic process; icosanoid biosynthetic process; and kidney development. Predicted to act upstream of or within lipid metabolic process. Located in intracellular membrane-bounded organelle. Is expressed in liver and urinary system. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human CYP4A11 (cytochrome P450 family 4 subfamily A member 11). PHENOTYPE: Mice homozygous for a null mutation display salt-sensitive hypertension, decrease sodium excretion, and decreased urine output. [provided by MGI curators] |