| Primary Identifier | MGI:7547405 | Allele Type | Transgenic |
| Attribute String | Dominant negative, Inserted expressed sequence | Gene | Tg(Myh6-Mybpc3*)262Rbns |
| Strain of Origin | Not Specified | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | A mutated mouse Mybpc3 cDNA is expressed under the control of a mouse alpha-MHC promoter. The Mybpc3 phosphorylation sites (Ser-273, Ser-282, Ser-302), along with two adjacent sites that could be potentially phosphorylated (Thr-272, Thr-281) were converted to alanine, and a sequence encoding the myc epitope was added to the construct. Lines 45, 262 and 272 were generated, but line 262 was selected for further study. |
