| Primary Identifier | MGI:109150 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 17428 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables DNA binding activity; DNA-binding transcription factor activity; and chromatin binding activity. Acts upstream of or within several processes, including cellular senescence; negative regulation of apoptotic signaling pathway; and regulation of DNA-templated transcription. Predicted to be located in nucleoplasm. Is expressed in several structures, including central nervous system; early conceptus; future brain; genitourinary system; and retina nuclear layer. Used to study Miller-Dieker lissencephaly syndrome. Orthologous to human MNT (MAX network transcriptional repressor). PHENOTYPE: Most homozygotes for a targeted null mutation are runted at birth and die within a few days, while mutant fibroblasts show abnormal cell cycling. Those homozygotes that survive are fertile and attain normal Heterozygotes for a conditional mammary epithelial specific knockout develop adenocarcinomas. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
