| First Author | Viant C | Year | 2014 |
| Journal | Nat Commun | Volume | 5 |
| Pages | 5108 | PubMed ID | 25355530 |
| Mgi Jnum | J:248351 | Mgi Id | MGI:6093584 |
| Doi | 10.1038/ncomms6108 | Citation | Viant C, et al. (2014) SHP-1-mediated inhibitory signals promote responsiveness and anti-tumour functions of natural killer cells. Nat Commun 5:5108 |
| abstractText | Natural killer (NK) cells are cytotoxic innate lymphoid cells that are involved in immune defense. NK cell reactivity is controlled in part by MHC class I recognition by inhibitory receptors, but the underlying molecular mechanisms remain undefined. Using a mouse model of conditional deletion in NK cells, we show here that the protein tyrosine phosphatase SHP-1 is essential for the inhibitory function of NK cell MHC class I receptors. In the absence of SHP-1, NK cells are hyporesponsive to tumour cells in vitro and their early Ca(2+) signals are compromised. Mice without SHP-1 in NK cells are unable to reject MHC class I-deficient transplants and to control tumours in vivo. Thus, the inhibitory activity of SHP-1 is needed for setting the threshold of NK cell reactivity. |
