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Publication : The p21 src genes of Harvey and Kirsten sarcoma viruses originate from divergent members of a family of normal vertebrate genes.

First Author  Ellis RW Year  1981
Journal  Nature Volume  292
Issue  5823 Pages  506-11
PubMed ID  6265801 Mgi Jnum  J:12007
Mgi Id  MGI:60268 Doi  10.1038/292506a0
Citation  Ellis RW, et al. (1981) The p21 src genes of Harvey and Kirsten sarcoma viruses originate from divergent members of a family of normal vertebrate genes. Nature 292(5823):506-11
abstractText  The Harvey and Kirsten strains of murine sarcoma virus encode enzymatically and serologically related p21 src proteins which are required for virally mediated cellular transformation. The genes in each virus encoding p21 show such extensive divergence from each other that cloned probes from these genes detect distinct sets of cellular genes in the DNA from several vertebrate species. These data suggest that cellular p21 sarc genes constitute a divergent family of vertebrate genes that can regulate the growth of cells.
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