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Protein Coding Gene : Spry2 sprouty RTK signaling antagonist 2

Primary Identifier  MGI:1345138 Organism  mouse, laboratory
Chromosome  14 NCBI Gene Number  24064
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0)

Enables ubiquitin-protein transferase inhibitor activity. Involved in several processes, including negative regulation of cell differentiation; negative regulation of cell projection organization; and regulation of signal transduction. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; lung development; and negative regulation of signal transduction. Located in several cellular components, including cytoskeleton; cytosol; and nucleus. Is expressed in several structures, including alimentary system; embryo mesenchyme; epithelium; future brain; and genitourinary system. Used to study achalasia; ciliopathy; intestinal pseudo-obstruction; and prostate cancer. Human ortholog(s) of this gene implicated in IgA glomerulonephritis. Orthologous to human SPRY2 (sprouty RTK signaling antagonist 2).
PHENOTYPE: Homozygous null mice exhibit enteric nerve hyperplasia which led to esophangeal achalasia and intestinal pseudo-obstruction. Mice also have intermediate to severe hearing loss with abnormalities in the organ of Corti and about half die prematurely. [provided by MGI curators]
  • synonyms:
  • sprouty RTK signaling antagonist 2,
  • Spry2,
  • sprouty2

Features --> Cross References

Genome

Sequence Feature Displayer

JG Browse Displayer

0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

2 Involved In Mutations

0 Strain

0 Transcripts

3 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

14 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

0 Driver For