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Allele : Tmc1<em2Ftpl> transmembrane channel-like gene family 1; endonuclease-mediated mutation 2, Robert Fettiplace

Primary Identifier  MGI:6715680 Allele Type  Endonuclease-mediated
Gene  Tmc1 Strain of Origin  C57BL/6J
Is Recombinase  false Is Wild Type  false
molecularNote  CRISPR/cas9 genome editing is used to introduce a W554L (TGG to CTG) mutation into exon 15 to modify residues near the putative pore of the channel. Three additional silent mutations were also created to add a BstAP1 enzyme restriction site.
  • mutations:
  • Nucleotide substitutions
  • synonyms:
  • Tmc1 p.W554L,
  • Tmc1 p.W554L
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

Trail: Allele

0 Driven By

3 Publication categories

Trail: Allele