| First Author | Look J | Year | 1995 |
| Journal | Am J Physiol | Volume | 269 |
| Issue | 1 Pt 1 | Pages | E91-8 |
| PubMed ID | 7631783 | Mgi Jnum | J:27473 |
| Mgi Id | MGI:74954 | Doi | 10.1152/ajpendo.1995.269.1.E91 |
| Citation | Look J, et al. (1995) Marked resistance of RAR gamma-deficient mice to the toxic effects of retinoic acid. Am J Physiol 269(1 Pt 1):E91-8 |
| abstractText | Excessive intake of retinol or of retinoic acid causes a syndrome of characteristic toxic effects known as hypervitaminosis A. To test the role of the nuclear retinoic acid receptor (RAR gamma) in this process we produced mice with a targeted disruption of the RAR gamma gene and examined toxic effects of repeated doses of retinoic acid and two other synthetic retinoids, Ro 15-1570 and Ro 40-6055. Surprisingly, homozygous mutant mice were resistant to fourfold higher doses of retinoic acid than wild-type mice as well as to elevated doses of the synthetic retinoids, indicating that RAR gamma may have a major role in mediating retinoid toxicity, a finding that possibly has practical implications for reducing the toxicity of synthetic retinoids in clinical use. |
