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Protein Coding Gene : Pycr2 pyrroline-5-carboxylate reductase family, member 2

Primary Identifier  MGI:1277956 Organism  mouse, laboratory
Chromosome  1 NCBI Gene Number  69051
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Predicted to enable pyrroline-5-carboxylate reductase activity. Predicted to be involved in L-proline biosynthetic process and cellular response to oxidative stress. Predicted to act upstream of or within amino acid biosynthetic process. Predicted to be located in mitochondrion. Is expressed in several structures, including alimentary system; brain; respiratory system; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 10. Orthologous to human PYCR2 (pyrroline-5-carboxylate reductase 2).
PHENOTYPE: Homozygous inactivation of this gene leads to limb clasping, decreased body weight, kyphosis, and reduced subdermal fat. [provided by MGI curators]
  • synonyms:
  • P5cr2,
  • MGI:1916301,
  • RIKEN cDNA 1810018M05 gene,
  • pyrroline-5-carboxylate reductase family, member 2,
  • Pycr2,
  • pyrroline-5-carboxylate reductase,
  • 1810018M05Rik

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0 Canonical

0 CDSs

0 Exons

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3 Involved In Mutations

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0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features


Gene --> Proteins


Mouse features --> Functions (GO terms)


Genes --> Homologs


3 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions


Gene --> Expression annotations


Genes/Features --> Phenotypes (MP terms)


Mouse features --> Human diseases


Mouse features --> Publications



0 Driver For