| First Author | Phalke SP | Year | 2019 |
| Journal | PLoS One | Volume | 14 |
| Issue | 6 | Pages | e0218827 |
| PubMed ID | 31237933 | Mgi Jnum | J:276731 |
| Mgi Id | MGI:6316417 | Doi | 10.1371/journal.pone.0218827 |
| Citation | Phalke SP, et al. (2019) gammadelta T cells shape memory-phenotype alphabeta T cell populations in non-immunized mice. PLoS One 14(6):e0218827 |
| abstractText | Size and composition of gammadelta T cell populations change dramatically with tissue location, during development, and in disease. Given the functional differentiation of gammadelta T cell subsets, such shifts might alter the impact of gammadelta T cells on the immune system. To test this concept, and to determine if gammadelta T cells can affect other immune cells prior to an immune response, we examined non-immunized mice derived from strains with different genetically induced deficiencies in gammadelta T cells, for secondary changes in their immune system. We previously saw extensive changes in pre-immune antibodies and B cell populations. Here, we report effects on alphabeta T cells. Similarly to the B cells, alphabeta T cells evidently experience the influence of gammadelta T cells at late stages of their pre-immune differentiation, as single-positive heat stable antigen-low thymocytes. Changes in these and in mature alphabeta T cells were most prominent with memory-phenotype cells, including both CD8+ and CD4+ populations. As previously observed with B cells, most of the effects on alphabeta T cells were dependent on IL-4. Unexpectedly, IL-4 seemed to be produced mainly by alphabeta T cells in the non-immunized mice, albeit strongly regulated by gammadelta T cells. Similarly to our findings with B cells, changes of alphabeta T cells were less pronounced in mice lacking all gammadelta T cells than in mice lacking only some, suggesting that the composition of the gammadelta T cell population determines the nature of the gammadelta-influence on the other pre-immune lymphocytes. |
