| First Author | Mayerl S | Year | 2020 |
| Journal | Stem Cell Reports | Volume | 14 |
| Issue | 5 | Pages | 845-860 |
| PubMed ID | 32302557 | Mgi Jnum | J:288976 |
| Mgi Id | MGI:6435333 | Doi | 10.1016/j.stemcr.2020.03.014 |
| Citation | Mayerl S, et al. (2020) Hippocampal Neurogenesis Requires Cell-Autonomous Thyroid Hormone Signaling. Stem Cell Reports 14(5):845-860 |
| abstractText | Adult hippocampal neurogenesis is strongly dependent on thyroid hormone (TH). Whether TH signaling regulates this process in a cell-autonomous or non-autonomous manner remains unknown. To answer this question, we used global and conditional knockouts of the TH transporter monocarboxylate transporter 8 (MCT8), having first used FACS and immunohistochemistry to demonstrate that MCT8 is the only TH transporter expressed on neuroblasts and adult slice cultures to confirm a necessary role for MCT8 in neurogenesis. Both mice with a global deletion or an adult neural stem cell-specific deletion of MCT8 showed decreased expression of the cell-cycle inhibitor P27KIP1, reduced differentiation of neuroblasts, and impaired generation of new granule cell neurons, with global knockout mice also showing enhanced neuroblast proliferation. Together, our results reveal a cell-autonomous role for TH signaling in adult hippocampal neurogenesis alongside non-cell-autonomous effects on cell proliferation earlier in the lineage. |
