First Author | Véron N | Year | 2009 |
Journal | Genes Dev | Volume | 23 |
Issue | 23 | Pages | 2705-10 |
PubMed ID | 19952105 | Mgi Jnum | J:154729 |
Mgi Id | MGI:4398749 | Doi | 10.1101/gad.553009 |
Citation | Veron N, et al. (2009) Retention of gene products in syncytial spermatids promotes non-Mendelian inheritance as revealed by the t complex responder. Genes Dev 23(23):2705-2710 |
abstractText | The t complex responder (Tcr) encoded by the mouse t haplotype is able to cause phenotypic differences between t and + sperm derived from t/+ males, leading to non-Mendelian inheritance. This capability of Tcr contradicts the concept of phenotypic equivalence proposed for sperm cells, which develop in a syncytium and actively share gene products. By analyzing a Tcr minigene in hemizygous transgenic mice, we show that Tcr gene products are post-meiotically expressed and are retained in the haploid sperm cells. The wild-type allele of Tcr, sperm motility kinase-1 (Smok1), behaves in the same manner, suggesting that Tcr/Smok reveal a common mechanism prone to evolve non-Mendelian inheritance in mammals. |