| First Author | Yucel G | Year | 2013 |
| Journal | Genes Dev | Volume | 27 |
| Issue | 11 | Pages | 1217-22 |
| PubMed ID | 23752588 | Mgi Jnum | J:199173 |
| Mgi Id | MGI:5500981 | Doi | 10.1101/gad.216556.113 |
| Citation | Yucel G, et al. (2013) State-dependent signaling by Cav1.2 regulates hair follicle stem cell function. Genes Dev 27(11):1217-22 |
| abstractText | The signals regulating stem cell activation during tissue regeneration remain poorly understood. We investigated the baldness associated with mutations in the voltage-gated calcium channel (VGCC) Cav1.2 underlying Timothy syndrome (TS). While hair follicle stem cells express Cav1.2, they lack detectable voltage-dependent calcium currents. Cav1.2(TS) acts in a dominant-negative manner to markedly delay anagen, while L-type channel blockers act through Cav1.2 to induce anagen and overcome the TS phenotype. Cav1.2 regulates production of the bulge-derived BMP inhibitor follistatin-like1 (Fstl1), derepressing stem cell quiescence. Our findings show how channels act in nonexcitable tissues to regulate stem cells and may lead to novel therapeutics for tissue regeneration. |
