Primary Identifier | IPR034674 | Type | Domain |
Short Name | STK_Kin4/ppk1 |
description | Saccharomyces cerevisiae Kin4 is a central component of the spindle position checkpoint (SPOC), which monitors spindle position and regulates the mitotic exit network (MEN) [, ]. Kin4 associates with spindle pole bodies in mother cells to inhibit MEN signaling and delay mitosis until the anaphase nucleus is properly positioned along the mother-bud axis. Kin4 activity is regulated by both the bud neck-associated kinase Elm1 and protein phosphatase 2A [, ].The fission yeast homologue is known as ppk1 []. |