| First Author | Iguchi T | Year | 2018 |
| Journal | Biochem Biophys Res Commun | Volume | 501 |
| Issue | 2 | Pages | 570-575 |
| PubMed ID | 29750959 | Mgi Jnum | J:271455 |
| Mgi Id | MGI:6280088 | Doi | 10.1016/j.bbrc.2018.05.044 |
| Citation | Iguchi T, et al. (2018) A BTB-ZF protein, ZNF131, is required for early B cell development. Biochem Biophys Res Commun 501(2):570-575 |
| abstractText | Members of the BTB-ZF transcription factor family play important roles in lymphocyte development. During T cell development, ZNF131, a BTB-ZF protein, is critical for the double-negative (DN) to double-positive (DP) transition and is also involved in cell proliferation. Here, we report that knockout of Znf131at the pre-pro-B cell stage in mb1-Cre knock-in mouse resulted in defect of pro-B to pre-B cell transition. ZNF131 was shown to be required for efficient pro-B cell proliferation as well as for immunoglobulin heavy chain gene rearrangement that occurs in the proliferating pro-B cells. We speculate that inefficient gene rearrangement may be due to loss of cell proliferation, since cell cycle progression and immunoglobulin gene rearrangement, which would occur in a mutually exclusive manner, may be interconnected or coupled to avoid occurrence of genomic instability. ZNF131 suppresses expression of Cdk inhibitor, p21(cip1), and that of pro-apoptotic factors, Bax and Puma, targets of p53, to facilitate cell cycle progression and suppress unnecessary apoptosis, respectively, of pro-B cells. There results demonstrate the essential roles of ZNF131 in coordinating the B cell differentiation and proliferation. |
