| Primary Identifier | IPR034979 | Type | Domain |
| Short Name | UPF3B_RRM-like |
| description | This entry represents the RNA recognition motif (RRM)-like domain in Upf3B, a human orthologue of yeast Upf3p and Caenorhabditis elegans SMG-4 []. It derives from X-linked gene UPF3B and is required for nonsense-mediated mRNA decay (NMD) in human []. Upf3B is a nucleocytoplasmic shuttling protein that associates selectively with spliced beta-globin mRNA in vivo []. Like other Upf3 proteins, Upf3B contains nuclear import and export signals, and a conserved domain with some similarity to an RNA recognition motif (RRM), indicating that it may be an RNA binding protein. |
