| First Author | Mimmack ML | Year | 1997 |
| Journal | Brain Res Mol Brain Res | Volume | 47 |
| Issue | 1-2 | Pages | 345-50 |
| PubMed ID | 9221934 | Mgi Jnum | J:41456 |
| Mgi Id | MGI:893934 | Doi | 10.1016/s0169-328x(97)00104-6 |
| Citation | Mimmack ML, et al. (1997) A novel splice variant of the cell adhesion molecule BIG-2 is expressed in the olfactory and vomeronasal neuroepithelia. Brain Res Mol Brain Res 47(1-2):345-50 |
| abstractText | We have cloned a mouse cDNA encoding a novel truncated form of the gene BIG-2 from the vomeronasal organ. The related proteins BIG-2 and BIG-1 possess a C-terminal glycosylphosphatidylinositol anchor, six immunoglobulin domains and four fibronectin type III repeats. They are related to certain axonal-associated cell adhesion molecules (AxCAMs) exhibiting most similarity to the TAG-1/F3 subgroup of neural cell adhesion molecules. The cDNA we have identified, termed BIG-2A, appears to represent a novel splice variant of BIG-2 possessing six Ig-like domains, a single fibronectin repeat and lacking the glycosylphosphatidylinositol-anchoring domain (GPI). To determine the expression of this gene, in situ hybridization analysis was performed in adult and developing mice using a riboprobe specific for BIG-2A. Maximum expression was observed in mature sensory cells of the vomeronasal neuroepithelium and a less intense signal was also evident in the olfactory neuroepithelium. These results suggest that alternative splicing of the BIG-2 gene transcript may play an important role in the organization of the vomeronasal and olfactory neuroepithelia. |
