| First Author | Xiang X | Year | 1990 |
| Journal | Science | Volume | 247 |
| Issue | 4945 | Pages | 967-9 |
| PubMed ID | 2305264 | Mgi Jnum | J:10325 |
| Mgi Id | MGI:58778 | Doi | 10.1126/science.2305264 |
| Citation | Xiang X, et al. (1990) Mini-mouse: disruption of the pygmy locus in a transgenic insertional mutant. Science 247(4945):967-9 |
| abstractText | A founder transgenic mouse harbored two different integration patterns of a transgene at the same locus, each of which gave rise to a similar autosomal recessive mutation. Mice of the mutant phenotype were of small stature but had normal levels of growth hormone. The disrupted locus was cloned, and a genetic and molecular analysis showed that the insertional mutants were allelic to a spontaneous mutant, pygmy. The mice should be a useful model for the growth hormone-resistant human dwarf syndromes and could lead to a greater understanding of the pathways involved in growth and development. |
