| First Author | Gonda Y | Year | 2022 |
| Journal | FEBS Lett | Volume | 596 |
| Issue | 22 | Pages | 2889-2897 |
| PubMed ID | 35665501 | Mgi Jnum | J:360038 |
| Mgi Id | MGI:7568852 | Doi | 10.1002/1873-3468.14417 |
| Citation | Gonda Y, et al. (2022) Astrocytic d-amino acid oxidase degrades d-serine in the hindbrain. FEBS Lett 596(22):2889-2897 |
| abstractText | d-Serine modulates excitatory neurotransmission by binding to N-methyl-d-aspartate glutamate receptors. d-Amino acid oxidase (DAO) degrades d-amino acids, such as d-serine, in the central nervous system, and is associated with neurological and psychiatric disorders. However, cell types that express brain DAO remain controversial, and whether brain DAO influences systemic d-amino acids in addition to brain d-serine remains unclear. Here, we created astrocyte-specific DAO-conditional knockout mice. Knockout in glial fibrillary acidic protein-positive cells eliminated DAO expression in the hindbrain and increased d-serine levels significantly in the cerebellum. Brain DAO did not influence levels of d-amino acids in the forebrain or periphery. These results show that astrocytic DAO regulates d-serine specifically in the hindbrain. |
